Selegiline anhedonia. Anhedonia is the lack of interest, enjoyment or pleasure.

Selegiline anhedonia But everything I have heard selegiline helps libido and anhedonia. Best. My long term bf was on 15mg daily for depression/PTSD for 6 months and stopped taking it about 5 weeks ago. Valheim Genshin Impact Minecraft Pokimane Halo Infinite Call of Duty: Warzone Path of Exile Hollow Knight: Silksong Escape from Tarkov Watch Dogs: Legion. After forty days I titrated down and quit after 46 days and started taking Niacinamide (Vitamin B3) 500mg twice a day for its anti-inflammatory properties that are similar to mirapex’s. It's the fourth day I'm not taking it, and even tho the med didn't really bring a significant change to my anhedonia/apathy, I'm missing the stimulating/energetic effect and I feel like my base state right now is worse then before starting the med. Crypto Much of the cessation of Selegiline use seems to come from people dosing improperly and impatiently due to the poor bioavailability and required time of accumulation needed before it can take proper effect. So maybe that was treating the double Antidepressant dose is around 60mg daily from studies, despite what Reddit says about saving costs by going sublingual, that was specifically for a formulation of selegiline made by zydis. My physical body took much longer to get in shape. Expand user menu Open settings menu. Members Online • ketaking1976. Selegiline Would it be worth taking it sublingually? From my understanding it avoids first pass metabolism and increases bioavailability?. Log In / Sign Up; Advertise on Anhedonia is the lack of interest, enjoyment or pleasure. They work on anhedonia because the Anhedonia is the lack of interest, enjoyment or pleasure. Parnate, Nardil) vs methylphenidate (or another stimulant), whether in combination or separately. When will I have an idea of whether this is likely to work for me? Thank you. I just read this paper , now i think most of what i wrote here may be wrong. My anhedonia was physiological, perhaps yours is a result of emotional trauma which indicates ketamine or psychedelics might work. Be the first to comment Nobody's responded to this post yet. I'd only Well, the dosage that has been used in studies has been up to 60 mg, and psychiatrists who prescribe oral selegiline often go up to near that dosage. Top. Well hello people Fighting with anhedonia since 2019 december Currently taking pramipexole doses sublingually So now want to change pramipexole to Selegiline and add Lithium also because my lithium level is 0. The feeling is a lot like the first time I started on sertraline 15yrs ago. However, I’m currently taking Selegiline at 5mg sublingual, which is supposed to be 8x, equal to 40mg oral. Business, Economics, and Finance. Sulbutiamine, Selegiline (MAOI), paroxetine (Parkinson's medication, NSI-189, modafinil (as a DRI), bupropion obviously - but also combines with sertraline which is a SDRI (for extra DRI Ki of 22 if I remember) - and optionally buspirone just for help with anxiety, tranylcypromine (MAOI). Each day I achieve a little more. Hey i just wanted to thank because at the time that u wrote the comment i was too scared to read it and ever realize what u were trying to exlain to me. Anhedonia is the lack of interest, enjoyment or pleasure. Now i'm healed, and it was a miracle. Tried bromantane already did nothing. Several people in this sub are or have been taking as much as 40-60 mg oral selegiline. It could be because chronic selegiline is much different to acute selegiline. There's really only one source that sells it right now but they recently added a Hi everyone im currently on 150mg of buropion and its my fifth week and im wanting to talk to my doctor and ask to try selegiline, does anyone have Skip to main content. And increasing dopamine via MAOI helps my anhedonia slightly but makes me emotionally volatile. Old. Since BPC157 also modulates the gut, it is not far fetched to think that it could be doing this by modulating certain microbes/genuses in the gut. I have been on selegiline for the past 12 days. Low dose Selegiline along with something like OmegaTAU is what I wish Wellbutrin would have done for me. Will this patch give me Selegiline 5mg, Moclobimide 300mg and Nortyptiline 10mg to cure anhedonia. Anhedonia is no joke when your depression makes you jaded. Deprenyl (Selegiline) does not work exclusively on dopamine. Oral to sublingual ratio AFAIR is 4 to 1. fubarbyads • You need 9-10 mg sublingual for full MAO inhibition. But oral is a waste of stuff Anyone tried this combo ? Want suggestions about this combo. I’ll give updates as I have them, reminders are welcome. I am too lazy to go look at my notes but I am still taking selegiline 5mg 4 times a week or so. I have enough for 50 days. Go to anhedonia r/anhedonia After starting selegiline for about a week (I used it in the past and had similar response) I get seriously antisocial. Members Online • ebin-t. Because is much more dopaminergic at common doses than Moclobemide, due to being a way stronger and selective MAO-B irreversible inhibitor (this pumps up dopamine and PEA levels). Members Online • So today is my straight second week on selegiline , started from 1. At the beginning I became more depressed and suicidal. Selegiline at a low dose, or the Emsam patch at a low dose, blocks MAO-B first, before it blocks MAO-A. I lack any will to interact with others and even do small talk. I've read it helps with anhedonia, that's what drew me to it, but would I need non-selective doses for that to happen Yes you'd likely need the higher dosages to treat anhedonia and depression effectively. No impact on anhedonia, although it made me feel more motivated. Not sure yet. If Unfortunately, in my country, Switzerland, they only offer Moclobemide, which does not work at all. I was going to increase the dose to 40mg to see if it would help with Everything makes sense in it and there's multiple user posts on Reddit that says Selegiline brings back their emotions / anhedonia remission. Just constant anhedonia every That's quite interesting, I also find selegiline to improve my motivation, but not anhedonia. how should i safely try using the selegiline if i want to have some Hi, anyone knows what is the situation with Selegiline and stimulants? Selegiline is working perfectly on anxiety and other aspects, but I feel a little more anhedonia, and that was already a big problem. Are you taking an MAOI? Going to? Want to but don't know how? Informed and want to help others? Something Emotional blunting/anhedonia caused by mirtazapine/Remeron even after getting off of it? I’m wondering if anyone has experience with mirt causing severe emotional blunting that did not go away after they quit taking it. With MAOIs when they work it's obviously a consistent improvement, considering pharmacodynamics of irreversible MAO inhibition. When I finally felt normal, hell better than ever before, I could not even consider getting back on here and talking about it - r/anhedonia A chip A close button. Find those things. If you have 10 mg tablets - it's simply the full tablet. No, it turns out some info here is alright. I'm with pramipexole and pirlindole now but no results yet Anhedonia (low emotional detail, lack of aesthetic appreciation, am limited to excited and boredom) Depression (low mood, numbness, lacking energy and motivation) Anxiety (Social anxiety) My questions. xSkynet69x • For ahedonia add Selegiline or Rasagiline to your stack. PPAP is great though. I have anhedonic TRD and i havent tried yet Selegiline in the high doses required to improve significantly TRD, which is around 60 mg/day orally or 7. I fixed my anhedonia with low dose NSI-189. When you have a higher baseline of dopamine, you'd have more stable dopaminergic signaling which I have severe anhedonia and have just been prescribed selegiline. Selegiline is not that great but EMSAM a special version of selegiline is said to be good and has a low side effect profile, moreover the diet doesn't really matter with emsam (despite what the FDA says) Maybe an increase in libido. So, I'd set my expectations going into this one. I only tried it up to 10 mg orally some months ago but only i noticed more color intensity, but ofc is still a very small dose for TRD. Selegiline should only be used subligualy or transdermaly (EMSAM) for depression. Log In / Sign Up; Advertise on Started by NeuroNootropic, 22 May 2015 selegiline, anhedonia, emotions Last Post by mbdrinker , 14 Jun 2022 : 18 replies; 10,492 views; mbdrinker Posted 22 May 2015; Expired selegiline in Brain Health Started by prunk, 24 Mar 2021 selegiline Last Post by prunk , 24 Mar 2021 : 0 replies; 1,237 views Anhedonia is the lack of interest, enjoyment or pleasure. Fast forward to today I use 1mg every other week or when needed. The way to do that is to take every day 2x5mg oral selegiline plus 2x5mg sublingual selegiline. Has anyone experienced anhedonia induced by a medication and using an MAOI help your anhedonia? Share Add a Comment. After which the effects become really subtle. Seems to reduce all depression and anhedonia while increasing energy and motivation, all under the 30mg suggested dose. a big part if my anhedonia i think is because of stress and if i feel a feeling bad or good trying to break trough someting just cuts if off. In my experience, 2-3mg sublingual 9mebc was MUCH stronger maoi compared to sublingual 1. Once I got anhedonia I finally found a doctor to give me mirtazapine again and now the only benefit I get is sleep but now it does absolutely nothing to depression/anhedonia . Q&A. To think there is some divine entity controlling your life is just stupid. Also I'm guessing you know about the pressor effect from tryamine reactions, truth is everyone is different, some people can go on just fine others are really sensitive. There may be some minor positive effects mood wise, maybe it can reduce your depression and anhedonia by 5%. 5mg and feeling good than before , anhedonia goes away slowly but finally goes away , my mind is clean and i can think like before anhedonia finally , just need time and increasing doses to feel everything 100% , i mean that i can feel joy from sex , watching stuff which been Hello people Anyone has any succes stories with pramipexole or Selegiline? Which one is better? I'm taking off from mirtazapine and want to start Advertisement Coins. When I took Paxil (paroxetine) for a year a couple of times, I wouldn't cry as much, and was eventually going out in the world and trying to do things in life a little more. It's more selective for MAO-B, but it does still inhibit MAO-A enough as the dose increases to be very useful for depression. I think sublingual route is stronger, but I have no idea to which degree. I'm less socially awkward, looking at sunsets is awesome, anhedonia: gone. That way has it much higher bioavalivility than oral, around 70% compared to 10% orally, and it also prevents in a significant part MAO inhibition in the intestines and liver, so the risk with tyramine is minimized. 5 mg sublingual. Surprisingly, my (previous) psychiatrist was very willing to prescribe pramipexole - I didn't even have to ask for it, he was the one who suggested it. Currently taking 5mg of selegiline sublingual and started also pramipexole 0. For 2 years I had really bad anhedonia, I couldn't feel anything, even anxiety or sadness. I used pure selegiline HCl. Each day my willpower improves. I had anhedonia and tried selegiline and did not notice much of an emotional boost or anything other than being able to lower my ADHD med dose and still have effectiveness. Premium Powerups Explore Gaming. So far I’d say I’m feeling something and I’ve been slowly picking up my old hobbies like puzzle solving, running, walking, exploring the woods, talking to friends. I’d like to try maoi, it’s pretty hard to get in my country though so would like to know first how effective it was for you. I get seriously annoyed by others presence, even more than I normally get. I live in Canada. 25 mg siblingual == 10 mg oral. Valheim Genshin 6. An MAOI like Moclobemide did more for my mood and anhedonia than Selegiline. In the future i could try it but im going Anyone of you people curing anhedonia with pramipexole or selegiline?? Or maybe with both of them?? What's your effects and on which dose are you? Advertisement Coins. Keywords: Selegiline. r/MAOIs A chip A close button. Controversial. It can be caused by drugs, trauma, depression, etc. Then, a few weeks after that, just before my summer exams started, I developed some pretty It took a LOT of time to persuade my psychiatrist to let me try selegiline, and even then it's a dose too low to help anhedonia (5mg a day). 5 orally and work my way up. Lets give some type of strength to each other, as anhedonics. After 42 days I tapered off but had started selegiline perhaps a week or so before. The antidepressants you are looking for are the mostly or purely dopaminergic ones like Selegiline, Pramipexole, LDA (Low Dose of Amisulpride), Rasagiline, Safinamide, Tianeptine and the irreversible MAOI's like Nardil, Parnate and Marplan. It is provided in the form of a capsule or tablet taken by mouth for Parkinson's disease and as a patch applied to skin for depression. A few here actually prefer oral selegiline over any other MAOIs! Anhedonia is the lack of interest, enjoyment or pleasure. Open comment sort options. NFL NBA Skip to main content. 6. New. I've gone through anhedonia, zero libido and zero pleasure from orgasms for about a year, it was one of the scariest things i've gone through. We don't know pharmacokinetics of ordinary buccal selegiline. I am conviced that a sinus infection got me Selegiline has been life changing for me, but I was taking it for the purposes of depression. So lowering my cortisol with phosphatdylserine did help my negative emotions, but makes me much more docile. But oral is a waste of stuff Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. Is recommend giving it a shot. I am feeling good, enjoying myself immensely and maybe even looking a bit younger. I could barely get the motivation to get out of bed most days Well hello people which is better to cure anhedonia take selegiline or pramipexole? Now im on tetracycling mirtazapine and thinking to switch Skip to main content. At the very least, I’d like to take it for its cognitive and neuroprotective benefits. Ive tried low dose abilify and found that effective too, selegiline I didn’t really like as I felt it was too dopamine concentrated for me Reply reply Im currently 15y/o, naturally got anhedonia when I was only 13 upvotes Anhedonia is the lack of interest, enjoyment or pleasure. 5 mg sublingually. Who is upvoting this? Nardil is useless for anhedonia? That'll come as news to a lot of people here who are benefiting from it. The same foundation with anhedonia (desensitized receptors) will be cumulatively down regulated. Here are several psychobiotics (single strain genus So I researched and apparently anhedonia and avolition are a common side effect in people who've been on ADs a long time. So want to try TMS to fully eliminate my anhedonia caused by lifely stress and pain Tried many meds but only self prescribed pramipexole and l-tyrosine gives me a hope , also ordered Selegiline oral tablets and want to start it with little dose like 2. Open menu Open navigation Go to Reddit Home. Or switch to Nardil or Parnate. My doctor recommended me selegiline patches. Personally I recommend on of the first ones I mentioned with Sélégiline : Mécanisme d'action La sélégiline est un inhibiteur spécifique de la monoamine-oxydase de type B ; elle agit également en inhibant le recaptage des catécholamines. Selegiline acts as a Hello. Thirteen days prior to quitting mirapex I started taking Selegiline 5mg an MAOI to insure my dopamine wasn’t getting eaten I'm not sure why this would happen. Also I've read it's safe but I'm That is precisely the reason I finally tried selegiline. stage Have any of you started on selegiline for anhedonia or anhedonic depression? I don’t want to go the med route but am researching selegiline. What didn’t work: ketamine, ssri’s, sarcosine + NAC, bromantane (may have helped relieve stress), Mr Happy stack, all the Vitamin B pathway stuff What am I getting myself into being prescribed 6mg selegiline patches for treatment resistant depression and anhedonia? I’m down to my last straw with the battle against anhedonia (extreme emotional blunting) I’ve tried many things, including adderall which I abused and made my anhedonia worse. Selegiline is an irreversible inhibitor of MAO-B, which means it knocks the MAO-B molecules out of activity, and new ones have to be produced, which takes about 2 weeks to get mostly back to normal on how long dopamine responses last. He seems more present and less like an So hello people I've got anhedonia since 2019 November , i think it's caused by Lifely stress , pain , marijuana (because in real case it gives me Coins. Note to drug developers: there is a There has been growing interest in the relationship between reward processing and clinical symptoms of depression such as anhedonia (loss of interest and response to pleasurable The primary effects of selegiline are inhibition of MAO-B and efficient use of intracranial dopamine. Now I am not sure I am doing the same or worse than when I started taking it. I think my boredom might be worse. Reply reply Lazy-Eagle-9729 • I'm considering getting it online as well if I can find a reputable source that can ship Posted by u/Beneficial-Face-9597 - 1 vote and no comments Selegiline also produces amphetamine metabolites of itself, which will be small in amount compared with what amphetamine users take, because the dose of selegiline is lower. Selegiline for motivation - posted in Brain Health: So how do people find this works in terms of motivation? I've heard stories about it actually making people want to do work/study things they didn't want to before they took it. Sports. Hey starting a postive post. So I buy this on the Internet (200 tablets of 10 mg for 80 dollars). I got a lot of help via this forum and I am trying to return the favor - this anhedonia is I suffer from anhedonia, I used Oral Selegiline since the beginning of June, max dose 10mg but some periods I took less. Posted by u/fellow90 - 1 vote and no comments I tried to comment on your anhedonia post a few minutes ago but it got locked or disappeared. I've been 100% clean from all drugs for about 4 years now, including drinking. remarkably improved. Please be sure to read the rules. Parnate worked but I couldnt sleep. 1K subscribers in the MAOIs community. Meanwhile in my quest to restore my energy I started taking Selegiline today at 1. So what happens is that if anything raises dopamine or phenethylamine (the brain's built-in amphetamine-class stimulant) the effect will stick around longer, even if there's lower overall production of Anhedonia is the lack of interest, enjoyment or pleasure. Wellbutrin is very weak on dopamine and is also very neurotoxic so is a bad choice. Welcome to r/anhedonia. g. I still take selegiline 5mg 4 or 5 days a week. Though, many people winging sublingual administration of drugs will not hold it in their mouth long enough for full absorption so they effectively get partially sublingual and partially oral, leading to less than optimized Anhedonia makes me feel myself like my IQ is probably below 60 . Most of selegiline gets converted to that when swallowed. I have continued researching day after day about the problems associated with anhedonia and I have discovered some important things, especially in relation to the pure symptoms of anhedonia. ADMIN A year ago i took mirapex / pramipexole 1 mg for about 42 days and my anhedonia went away. Moreover, selegiline is known to reinforce the intracranial phenylethylamine (PEA) activity . It actually increases the breakdown of dopamine and further increases radical species and oxidative stress. It’s only half effective now too since I tried Cymbalta. Members Online • I think maybe the first effect of selegiline is a more focused sort of motivation. I took a dose of 2. Anhedonia mostly gone at this point. I currently take methylene blue for its reversible inhibition of MAOa, and it But then what for anhedonia? MAOIs like selegiline are one of the few things that has potential to help. If high norepinephrine is part of the cause of someone's anhedonia, that could make it worse. Still working on ADHD. Pretty much nobody has ever reported any strong effects from taking low dosages of What sublingual dose would I need for MAO-A for depression and specifically anhedonia? Share Add a Comment. Selegiline has been life changing for me, but I was taking it for the purposes of depression. New comments cannot be posted. I've been taking 5mg orally with food for three days now, and while I feel a slight increase in motivation, the anhedonia remains unaffected. Every time I take Selegiline I have a positive effect on motivation in just the 3rd week which disappears quickly after that. And Selegiline is pretty strong! 9mebc had some punch to it, definitely a strong chemical. First of all, let me tell you that in my case I have anhedonia induced by ssri to treat anxiety. Anyone looking to try this for anhedonia or depression, I would advice not to. Anyone tried this combo ? Want suggestions about this combo. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. The aim of the study is to investigate the acute effects of a single dose of selegiline (an irreversible mo I wanted to do another trial of 9-me-bc since I had so much success with the last 2 in terms of treating anhedonia and resensitizing dopamine. And selegiline is not prescribed for depression here. Share Add a Comment. 0 coins. 250mg I was also like this on selegiline, but also without the selegiline and before I added phosphatdylserine to my stack (which lowers cortisol). I eventually took a LA motorcycle training course in which I drove too fast around a corner, laid my bike down and felt zero adrenaline, fear All psych medications including ssris, snris, tricyclics, tetracyclics, antipsychotics (commonly presxribed for anxiety even though theyre usually not effective and risky), benzodiazapines, gabapentinoids and even buspar and meds like abilify (both buspar and abilify gave me some of the worst emotional apathy ive ever experienced ontop of physically feeling like a zombie) all Posted by u/[Deleted Account] - 12 votes and 21 comments Anhedonia is the lack of interest, enjoyment or pleasure. 25 mg going to 2 mg or so. Thinking about Anhedonia is the lack of interest, enjoyment or pleasure. r/anhedonia A chip A close button Anhedonia is the lack of interest, enjoyment or pleasure. Posted by u/Own_Beat9208 - 3 votes and 8 comments I recently ordered some selegiline to experiment with and combat anhedonia/ lack of motivation. Selegiline is an MAOI (mono-amine oxidase inhibitor) and one of the medications on the list of medications for anhedonia here ranked by effectiveness. It's like my brain switched on and I'm waking from a long coma. And yea. 5mg sublingually (halving one 5mg 6-10 mg selegiline/1 mg rasagiline At low doses selegiline and rasagiline are selective for MAO-B, meaning they shouldn't produce serotonin syndrome or cheese effect as long as you don't attempt to abuse them. But for me the effects are only apparent during weeks 3 and 4. My new dr is not open to any new suggestions. Does anybody know how long I should take it for? I can't find Does wellbutrin or/and selegiline work on dopamine levels and motivation/anhedonia, just as SSRI's work on serotonine levels and anxiety/ocd, such as Fluoxetine? Concerta, Adderal and Vyvanse are great, but I would rather have something that works on my motivation/anhedonia much more "steadily" and "long-term". 25mg per day, and withing 2 weeks I started to feel almost normal again. Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease The Selegiline form I used was Selegiline HCL which is the normal oral tablets that can be found online cheaper than EMSAM or Zelapar. In the process of dealing with anhedonia, individuals often have several questions as they navigate their emotional numbness and seek understanding and support. It took a LOT of time to persuade my psychiatrist to let me try selegiline, and even then it's a dose too low to help anhedonia (5mg a day). sorry but my english is very bad. The worst features of it are absence of hunger , no sex drive and poor energy. I think an antidepressant like selegiline, that I'm taking now for three weeks again, and had for some weeks last year, is enough to treat the loss of interest and energy. Also tried ket I've been on selegiline (INTAS Indian generic) for 1 month, 1. I already tried the common things like nortriptyline pramipexole selegiline bupropion nac sarcosine nsi 189 Until summer I'm planning to try Psychdelics, Deschloroketamine (since I cant access ketamine), and maois and TRP + PCT (for a possible PSSD), and if I had a partial response I would start augmenation strategies. Selegiline is more effective as an antidepressant because is a CAE and it can reach a full MAO inhibition easier, but also Rasaline can be effective for depression in doses higher than 2 mg/day Zydis is a branded sublingual formulation of selegiline and this study suggests 1. Sort by: Best. The last one to try is this, has it helped anyone and has anyone tried it? Actually selegiline, which I've taken by prescription in some months, takes a lot longer to wear off. Its not very common to prescribe meds off label. However more and more research is indicating that this is a gut-brain axis dysfunction. Is it okay if I take selegiline together? If possible, please advise on what capacity is best. Now I don't have anxiety, but I also can't get my head to Anhedonia is the lack of interest, enjoyment or pleasure. Wellbutrin is not dopaminergic enough. even if its false hope. That will practically stop the excess GABA-A which has been inhibiting Dopamine from being released from neurons. Valheim Genshin Impact Minecraft Pokimane Halo Infinite Call of Duty: Warzone Path of Exile Hollow Knight: Silksong Escape from Tarkov Watch Dogs: Here's a list of some other things where I found studies that say they can increase SIRT1 activation, which other studies say is something that goes down in depression on average, and something that has neural connection effects (which we think may account for some anhedonia or emotional numbness): PQQ, CoQ10, high dose vitamin C, regular exercise, lipoic acid, vitamin Anhedonia is the lack of interest, enjoyment or pleasure. Are you taking an MAOI? Going to? Want to but don't know how? Informed and want to help others? Something Was just prescribed Selegiline for anhedonia but I’ve been reading that it may or may not work for that. Selegiline is way superior for low hedonic tone related issues like anhedonia, low motivation, lack of emotional response, low libido, etc. 25mg Selegiline. After two months of increasingly frequent promising flickers of feeling okayness, I now feel great all the time. That explains, oral selegiline can seem I have tried every medication in the book and nothing has helped. Selegiline for MAO-B, Moclobimide as a RIMA and Nortptiline to potentiate the precursour offect as I can't get the trans-dermal patch version of selegiline. 6 to 1. I'm looking for a way to buy Emsam patches online, current places that are guaranteed/safe. It seems We found that D1 receptors mediate an effect on despair behavior, D2 receptors mediate an effect on anhedonia, and both D1 and D2 receptors contribute to the protective Research needs to be done to see if anti-Parkinson MAOIs like rasagiline and selegiline—which increase patients’ dopamine—are able to treat anhedonia. 00 and normal level is 0. Selegiline worked fairly good the first days, then it turned me paranoid and aggressive. Although ive heard parnate is better All other meds outside MAOIs like SSRI/SNRI can cause anhedonia. Son intérêt dans la maladie de Parkinson réside dans la possibilité de renforcer l'action de la lévodopa en augmentant et surtout en prolongeant les taux plasmatiques utiles de dopamine . Would it be ill advised to test selegiline if I already have low COMT? I have the rs4680 polymorphism COMT A/A which is related to slower breakdown of dopamine and being more prone to anxiety. After more than two years in hell I figure I can be old, but I can’t be old and miserable and I have always been an empiricist. (2) Selegiline inhibits MAO-B, and according to one of the studies on what selegiline does, MAO-B doesn't break down dopamine much directly, and mainly makes GABA through a different pathway Anhedonia is the lack of interest, enjoyment or pleasure. 25mg sublinguall and increased to 2. That was a year and almost a half ago. 5mg , little doses of selegiline only inhibits MAO-B and it doesn't need any diet restrictions 13K subscribers in the anhedonia community. Then I added citalopram. Members Online • Garnetto56. I’ve suffered from a condition called anhedonia for 7 years. Members Online. Lifelong anhedonia, which really took a turn for the worse a few years ago to the point I couldn't even laugh and only danger could get me going. What was your dosage and how did you take it Anhedonia is the lack of interest, enjoyment or pleasure. Two weeks in my Anhedonia started lifting and by week three it was gone. Moclobemide is only maoi available in my country so i was wondering can it help with anhedonia? If yes how much? Share Sort by: Best. I would appreciate your thoughts on this. Norepinephrine is broken down by MAO-A, so oral selegiline would increase the oxidative stress for individuals who have this condition, and that lowers dopamine. Is this true?Also, it seems that the main function of this Nootropic/drug is for memory, but how does it go for concentration and attentiveness? I'm Moclobemide is weak, it might be better than SSRIs at 1200 mg though but at this dose the MAOI diet likely apply. But it's like Selegiline that I tried and which doesn't work very well either. Possibly look into low/high acetylcholine, low serotonin, and low testosterone as Anhedonia is the lack of interest, enjoyment or pleasure. 25 mg + Seroquel low-dose for the beginning and 15 mg/no Seroquel for the end of month Skip to main content. Hope this info is helpful! Feel free to ask more, cheers Before Anhedonia I was put on Mirtazapine and it was an absolutely amazing. L-tyrosine will be stronger on selegiline because selegiline upregulates the enzyme that turns tyrosine into dopamine (or, an intermediate metabolite) I believe. Also ibogaine is a bad recommendation because ibogaine cause dopamine inhibition. I take 20-25mg. But during all of this I've noticed that it intensifies my I have been taking 30mg oral selegiline for a month. Supplementing with methyl-b-vitamins helped some more, but did not solve. 2 as i know from analys. I'm wondering if anyone has experience with managing anhedonia with both an irreversible MAOI (e. Add a Comment. I am not taking selegiline yet Locked post. I’ve had anhedonia for about a year and a half from taking NAC. Log In / Sign Up; Advertise on Reddit Higher dose selegiline inhibits MAO-A somewhat too, but the levoamphetamine metabolite of selegiline, mainly from oral digestion of it, raises norepinephrine release. 2K subscribers in the MAOIs community. Hello everyone I have anhedonia and depression. I was prescribed 5mg tablets but will start with 2. Are there any contraindications here? Currently taking selegiline sublingual doses for My anhedonia , before tried many meds but only agomelatine gives me a hope in case of real anhedonia , i mean in feelings and life pleasure , so maybe i can safely add 25mg of agomelatine to my current med ? Selegiline is way superior for low hedonic tone related issues like anhedonia, low motivation, lack of emotional response, low libido, etc. Thats also my opinion Basically I had anhedonia a couple of years due to poly-drug abuse (mostly prescription ritalin and MDMA). We don't know a lot about this stuff, actually. Posted by u/Zieriso - 5 votes and 23 comments Hello, I have a similar experience in 2020, I took selegiline sublingually for half a year to completely inhibit MAO a and b as self-medication for depression, the first month was the worst, as if I was taking a large amount of phenylpiracetam with caffeine, like a very bursting anhedonia from NMDA agonist, acetylcholine , after adaptation it Already told you 5000x times before that selegiline in low dosages has barely any effect on anhedonia, depression or that you even feel anything whatsoever other than mild cognitive enhancement. 5mg sublingual equals 10mg oral, but they don't notice that it's true for Zydis Zelapar which is different from ordinary selegiline tablets. I wonder if selegiline would increase their addictiveness I think it'd be the opposite. After 2mg sublingual 9mebc 4 days apart, I began having legitimate panic attacks when I would blaze - first time that They say 1. Those are the ones that really increase dopamine and are motivating. Can't enjoy alcohol, drugs or music or anything else, let alone feeling genuine love and sympathy. Reply reply sasacarw • Believe in yourself, belive in love, belive in having a purpose in life. Get app Get the Reddit app Log In Log in to Reddit. Does anyone know, what stimulants I can combine with Selegiline? Or what supplements would give me a big motivational and/or energy boost Anhedonia is the lack of interest, enjoyment or pleasure. Rasagiline is much more selective for MAO-B than Selegiline and is more neuroprotective due to it's main neuroprotective metabolite 1-(R)-aminoindan. When I took Paxil Yes you can comeback to normal, i got anhedonia twice from meds, There has been growing interest in the relationship between reward processing and clinical symptoms of depression such as anhedonia (loss of interest and response to pleasurable activities). Anyway, after about 5 weeks, I resumed selegiline again at around 1. Within a day I could feel it working and this was just with one single 5mg sublingual dose. There is a potent combo against anhedonia and consist of Moclobemide + Selegiline + Memantine. Also, be sure to exercise a bit Hey man its tough - dealing with stress and antibiotics induced anhedonia. It has more catecholaminergic activity enhancing activity than Selegiline and no mao-b inhibition. siuk oqncr pasb wuc cvinrual ywpc gxvlum cyoe egpb codg